The effects of deep and light propofol anesthesia on stress response in patients undergoing open lung surgery: a randomized controlled trial
نویسندگان
چکیده
BACKGROUND This prospective, randomized controlled study was undertaken to compare stress hormone response to open thoracotomy for lung resection at different anesthetic depths, as determined by bispectral index (BIS) monitoring, in patients under propofol-remifentanil anesthesia. METHODS Forty-eight adult patients scheduled for lung resection surgery using one-lung ventilation were randomly assigned to either a deep anesthesia group (BIS score of 40 ± 5, n = 24) or a light anesthesia group (BIS score of 60 ± 5, n = 24) by adjusting propofol infusion rates. Blood norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol levels were measured before the induction of anesthesia, at the end of surgery, and at 2 hours postoperatively. Blood glucose, hemodynamic, and oxygenation-ventilation variables, and postoperative outcomes were also measured. RESULTS Norepinephrine and epinephrine levels remained unchanged over time in the deep group, but norepinephrine levels significantly increased in the light group at 2 h after surgery than at baseline (P = 0.007 and 0.004, respectively). Temporal changes in norepinephrine, but not in epinephrine, were significantly different between the two groups (P = 0.036). Plasma glucose levels in the light group increased with time and were significantly higher than in the deep group at the end of surgery (P = 0.002). CONCLUSIONS A deep level of anesthesia achieved using high propofol infusion rates during lung surgery provided lower perioperative norepinephrine and glucose responses than light level of anesthesia during the early postoperative period but failed to affect immediate postoperative outcomes.
منابع مشابه
Comparison of Anesthesia with Sevoflurane and Propofol on Extubation time and Recovery Parameters During Cataract Surgery
Background: One of the most common outpatient surgeries is cataract surgery which requires a short anesthesia with fast recovery time providing minimal complications. This study aimed to compare sevoflurane with propofol in terms of extubation time and recovery parameters in patients undergoing cataract surgery. Materials and Methods: This randomized controlled clinical trial recruited 60 ...
متن کاملEffect of Transcranial Alternating Current Stimulation on Anxiety and Hemodynamic Response in Patients Undergoing Surgery: A Double-Blind Controlled Clinical Trial
Background: Pre-op anxiety has adverse effects on the patientchr('39')s anesthesia and treatment. Currently, electrical interventions are widely used as non-invasive methods to control pre-op anxiety and may have advantages as compared with medical therapies. This study aimed to determine the effect of transcranial alternating current stimulation on anxiety and hemodynamic response of patients ...
متن کاملThe effect of two different propofol doses on the prevention of nausea and vomiting in discectomy surgery under spinal anesthesia: A triple-blind randomized clinical trial
Introduction: The occurrence of nausea and vomiting is one of the most common complications after surgery. Considering the preventative effect of Pofol on such PONV, the present study evaluated the effect of two different Propofol doses on the prevention of nausea and vomiting in discectomy surgery. Materials and Methods: The present controlled triple-blind clinical trial was performed on 48 pa...
متن کاملComparing Effects of Listening to Nature Sounds and Lavender Inhalation on Hemodynamic Parameters among Patients Undergoing Cataract Surgery with Regional Anesthesia: A Randomized Controlled Trial
Background and purpose: Candidates for cataract surgery have high anxiety and worry for various reasons which may cause changes in their hemodynamic parameters. Maintaining hemodynamic stability during anesthesia and surgery is very important. This study aimed at comparing the effects of listening to nature sounds and lavender inhalation on hemodynamic parameters in patients undergoing cataract...
متن کاملThe effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial
Background: Coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass pump may cause systemic inflammatory reactions by releasing cytokines which leads to multiple organ failure. Vitamin C has anti-inflammatory and antioxidant properties. The study aimed to determine the effect of vitamin C on inflammatory markers and atrial fibrillation in patients undergoing CABG. Materials and ...
متن کامل